PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection
نویسندگان
چکیده
منابع مشابه
PPARγ-Coactivator-1α, Nicotinamide Adenine Dinucleotide and Renal Stress Resistance.
With one of the highest mitochondrial densities in the body, the kidneys consume approximately 10% of total oxygen while constituting 0.5% of body mass. Renal respiration is linear to solute extraction, linking oxidative metabolism directly to tubular function. This fundamental role of mitochondria in renal health may become an "Achilles heel" under duress. Acute kidney injury (AKI) related to ...
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ژورنال
عنوان ژورنال: Nature
سال: 2016
ISSN: 0028-0836,1476-4687
DOI: 10.1038/nature17184